High Levels of Nitric Oxide Synthase Activity are Associated with Nasal Polyp Tissue from Aspirin-sensitive Asthmatics

@article{Parikh2002HighLO,
  title={High Levels of Nitric Oxide Synthase Activity are Associated with Nasal Polyp Tissue from Aspirin-sensitive Asthmatics},
  author={Alex A. Parikh and Glenis Kathleen Scadding and Penney A. Gray and Maria G Belvisi and Jerald A Mitchell},
  journal={Acta oto-laryngologica},
  year={2002},
  volume={122 3},
  pages={
          302-5
        }
}
The pathogenesis of aspirin intolerance remains unclear. Inducible nitric oxide synthase (iNOS) expression is upregulated in nasal polyp epithelium, implying a role for nitric oxide (NO) in its formation. We decided to compare iNOS activity in polyp tissue from patients with and without aspirin intolerance. Nasal polyp tissue was collected from 15 patients undergoing routine nasal polypectomy. These patients were classified into three groups: Group A comprised patients with nasal polyps without… CONTINUE READING
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