High Levels of Lp(a) With a Small Apo(a) Isoform Are Associated With Coronary Artery Disease in African American and White Men

@article{Paultre2000HighLO,
  title={High Levels of Lp(a) With a Small Apo(a) Isoform Are Associated With Coronary Artery Disease in African American and White Men},
  author={Furcy Paultre and Thomas A. Pearson and Henry F.C. Weil and Catherine H. Tuck and Merle Myerson and Jill Rubin and Charles K. Francis and Herbert F. Marx and Edward F. Philbin and Roberta G. Reed and Lars Berglund},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association},
  year={2000},
  volume={20},
  pages={2619-2624}
}
  • F. PaultreT. Pearson Lars Berglund
  • Published 1 December 2000
  • Medicine
  • Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association
Abstract—Elevated levels of lipoprotein(a) [Lp(a)] and the presence of small isoforms of apolipoprotein(a) [apo(a)] have been associated with coronary artery disease (CAD) in whites but not in African Americans. Because of marked race/ethnicity differences in the distribution of Lp(a) levels across apo(a) sizes, we tested the hypothesis that apo(a) isoform size determines the association between Lp(a) and CAD. We related Lp(a) levels, apo(a) isoforms, and the levels of Lp(a) associated with… 

Tables from this paper

Relation of Apo(a) Size to Carotid Atherosclerosis in an Elderly Multiethnic Population

It is suggested that molecular properties of apo(a) are important in determining the atherogenicity of Lp(a), which is a novel risk factor for atherosclerosis and whose role in multiracial populations has been debated.

Study of Apo(a) Length Polymorphism and Lipoprotein(a) Concentrations in Subjects with Single or Double Apo(a) Isoforms

Assessment of cardiovascular risk should take into account the threshold effect at 20 K and the absence of influence of the minor apo(a) isoform, as well as the relationship between apo (a) size and Lp( a) concentration.

High levels of inflammatory biomarkers are associated with increased allele-specific apolipoprotein(a) levels in African-Americans.

Findings indicate that proinflammatory conditions result in a selective increase in medium-sized apo(a) levels in African-Americans and suggest that inflammation-associated events may contribute to the interethnic difference in Lp(a), but not in Caucasians.

PCSK9 in African Americans and Caucasians in Relation to Lp(a) Level, Apo(a) Size and Heritability

Among African Americans, but not Caucasians, PCSK9 levels were associated with isoform-specific Lp(a) levels carried on larger, butNot smaller, apo( a) sizes.

Heterozygous apolipoprotein (a) status and protein expression as a risk factor for premature coronary heart disease.

APO(a) phenotyping might be used in subjects with hyperlipoproteinemia a as a powerful marker to assess the risk of premature CHD because heterozygous status, mainly when both isoforms are equally expressed, is associated with higher cardiovascular risk.

Polymorphisms in the Apolipoprotein(a) Gene, Plasma Lp(a) and Cardiovascular Risk

Large and complex association and family studies in different populations, together with in vitro expression and functional studies, should clarify the importance of so far identified positive apo(a) polymorphism-plasma Lp(a), to identify a real effect of single polymorphism on Lp (a) phenotype in the future.

Low Molecular Weight Apolipoprotein(a) Phenotype Rather Than Lipoprotein(a) Is Associated With Coronary Atherosclerosis and Myocardial Infarction

The combination of Lp( a) level above 50 mg/dL and LMW apo(a) phenotype increases the risk of severe coronary atherosclerosis, regardless of other risk factors.

Lipoprotein(a) and its position among other risk factors of atherosclerosis.

Elevated Lp(a) level is suggested to be an independent risk factor of CHD in carriers of other important CHD risk factors, caused in part due to linkage to a restricted range of apo( a) gene length isoforms.
...

References

SHOWING 1-10 OF 42 REFERENCES

Lp(a) concentration and apo(a) isoform size. Relation to the presence of coronary artery disease in familial hypercholesterolemia.

Study of the relation between the concentration of lipoprotein(a) in plasma, apolipoprotein (a) [apo(a)] phenotype, and the clinical expression of coronary artery disease (CAD) in a previously described cohort of patients with familial hypercholesterolemia and an appropriate population of control subjects shows that on the basis of Lp(a), there is no significant difference between FH patients with and without signs or symptoms of CAD.

Coronary artery disease is associated with increased lipoprotein(a) concentrations independent of the size of circulating apolipoprotein(a) isoforms.

Isoform mobility, the number of isoform bands expressed, and the presence of CAD were the three most important independent predictors of Lp(a) concentration (descending order).

Apo(a) isoforms predict risk for coronary heart disease. A study in six populations.

The data demonstrate that alleles at the apo( a) locus determine the risk for CHD through their effects on Lp(a) concentrations across multiple populations with large differences in CHD frequency and risk factor profiles.

No association between plasma lipoprotein(a) concentrations and the presence or absence of coronary atherosclerosis in African-Americans.

The results suggest that the plasma concentration of Lp(a) is not an independent risk factor for coronary artery disease in African-Americans.

The Apo(a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans.

It is proposed that the higher plasma levels of Lp(a) in Africans are likely due to a yet-to-be-identified trans-acting factor that causes an increase in the rate of secretion of apo( a) or a decrease in its catabolism.

Role of lipoprotein(a) and apolipoprotein(a) phenotype in atherogenesis: prospective results from the Bruneck study.

Lp(a) plasma concentrations predicted the risk of early atherogenesis synergistically with high LDL cholesterol and low molecular weight phenotypes emerged as one of the strongest risk predictors of advanced stenotic atherosclerosis.

Lipoprotein[a] concentrations and apolipoprotein[a] phenotypes in Caucasians and African Americans. The CARDIA study.

The previously described inverse relationship between apo[a] size and Lp[ a] concentration was generally confirmed in Caucasians, but the B phenotype had lower Lp,[a] levels than the S1 or S2 phenotype, and in African Americans, both the B and S1 phenotypes had lower S2 phenotypes.

Predictive value of electrophoretically detected lipoprotein(a) for coronary heart disease and cerebrovascular disease in a community-based cohort of 9936 men and women.

In this cohort of 9936 men and women initially free of cardiovascular disease who were followed up for 14 years, Lp(a) was a significant predictor of risk of future CAD and was a weak risk factor for CVD in men and was not asignificant predictor of CVD risk in women.