High Levels of Lp(a) With a Small Apo(a) Isoform Are Associated With Coronary Artery Disease in African American and White Men

  title={High Levels of Lp(a) With a Small Apo(a) Isoform Are Associated With Coronary Artery Disease in African American and White Men},
  author={Furcy Paultre and Thomas A. Pearson and Henry F.C. Weil and Catherine H. Tuck and Merle Myerson and Jill Rubin and Charles K. Francis and Herbert F. Marx and Edward F. Philbin and Roberta G. Reed and Lars Berglund},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association},
  • F. PaultreT. Pearson Lars Berglund
  • Published 1 December 2000
  • Medicine
  • Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association
Abstract—Elevated levels of lipoprotein(a) [Lp(a)] and the presence of small isoforms of apolipoprotein(a) [apo(a)] have been associated with coronary artery disease (CAD) in whites but not in African Americans. Because of marked race/ethnicity differences in the distribution of Lp(a) levels across apo(a) sizes, we tested the hypothesis that apo(a) isoform size determines the association between Lp(a) and CAD. We related Lp(a) levels, apo(a) isoforms, and the levels of Lp(a) associated with… 

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