High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4.

Abstract

Human drug-metabolizing cytochrome P450 3A4 (CYP3A4) is a dynamic enzyme with a large and highly malleable active site that can fit structurally diverse compounds. Despite extensive investigations, structure-function relationships and conformational dynamics in CYP3A4 are not fully understood. This study was undertaken to engineer a well-expressed and… (More)
DOI: 10.1021/acs.biochem.7b00334

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