High-Level Expression of the Malaria Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 and Induction of Antibodies That Inhibit Erythrocyte Invasion

@article{Kocken2002HighLevelEO,
  title={High-Level Expression of the Malaria Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 and Induction of Antibodies That Inhibit Erythrocyte Invasion},
  author={C. Kocken and C. Withers-Martinez and M. Dubbeld and A. van der Wel and F. Hackett and M. Blackman and A. Thomas},
  journal={Infection and Immunity},
  year={2002},
  volume={70},
  pages={4471 - 4476}
}
  • C. Kocken, C. Withers-Martinez, +4 authors A. Thomas
  • Published 2002
  • Biology, Medicine
  • Infection and Immunity
  • ABSTRACT Apical membrane antigen 1 (AMA-1) is a highly promising malaria blood-stage vaccine candidate that has induced protection in rodent and nonhuman primate models of malaria. Authentic conformation of the protein appears to be essential for the induction of parasite-inhibitory antibody responses. Here we have developed a synthetic gene with adapted codon usage to allow expression of Plasmodium falciparum FVO strain AMA-1 (PfAMA-1) in Pichia pastoris. In addition, potential N-glycosylation… CONTINUE READING
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