High LIN28A and PLK4 co-expression is associated with poor prognosis in epithelial ovarian cancer

@inproceedings{He2018HighLA,
  title={High LIN28A and PLK4 co-expression is associated with poor prognosis in epithelial ovarian cancer},
  author={Yao He and Hui Wang and Meina Yan and Xinxin Yang and Rong Shen and Xiaoge Ni and Xiaokun Chen and Peifang Yang and Miao Miao Chen and Xiaodong Lu and Genbao Shao and Xiaoming Zhou and Qixiang Shao},
  booktitle={Molecular medicine reports},
  year={2018}
}
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. LIN28 homolog A (LIN28A) is a RNA‑binding protein, which serves a fundamental role in cell development and pluripotency. Polo‑like kinase 4 (PLK4) is a member of the polo‑like kinase family, which primarily takes part in the mitotic regulation. Overexpression of LIN28A has been demonstrated in ovarian cancer; however, the expression of PLK4 and the correlation between the expression of LIN28A and PLK4 in EOC has not… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Activity of the novel polo - like kinase 4 inhibitor CFI - 400945 in pancreatic cancer patient - derived xenografts

I Lohse, J Mason, +3 authors DW Hedley
  • Oncotarget
  • 2017

Clinical use of cancer biomarkers in epithelial ovarian cancer : Updated guidelines from the european group on tumor markers

G Sölétormos, MJ Duffy, +7 authors PH Petersen
  • Int J Gynecol Cancer
  • 2016