High LIN 28 A and PLK 4 co ‐ expression is associated with poor prognosis in epithelial ovarian cancer

@inproceedings{Yao2018HighL2,
  title={High LIN 28 A and PLK 4 co ‐ expression is associated with poor prognosis in epithelial ovarian cancer},
  author={He Yao and H Wang and Meina Yan and Xinxin Yang and Rong Shen and NI XIAOGE and Xiaokun Chen and Peifang Yang and Miao Chen and Lu Zhu Li Xiaodong and Genbao Shao and Xiaoming Zhou and Qixiang Shao},
  year={2018}
}
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. LIN28 homolog A (LIN28A) is a RNA‐binding protein, which serves a fundamental role in cell development and pluripotency. Polo‐like kinase 4 (PLK4) is a member of the polo‐like kinase family, which primarily takes part in the mitotic regulation. Overexpression of LIN28A has been demonstrated in ovarian cancer; however, the expres‐ sion of PLK4 and the correlation between the expression of LIN28A and PLK4 in EOC has not… CONTINUE READING

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