High-LET radiations induce a large proportion of non-rejoining DNA breaks

@article{Ritter1977HighLETRI,
  title={High-LET radiations induce a large proportion of non-rejoining DNA breaks},
  author={Mark A. Ritter and J. E. Cleaver and Cornelius A. Tobias},
  journal={Nature},
  year={1977},
  volume={266},
  pages={653-655}
}
THE mechanisms by which mammalian cells are killed by ionising radiation have not been explained at the molecular level and radiations with a high linear energy transfer (LET) can provide an important tool for investing these mechanisms. High-LET radiations, such as neutrons, π-mesons and low-energy heavy ions are known to kill bacteria1,2, yeast3,4, and mammalian cells in vitro5–9 more efficiently per unit dose than radiations with diffuse patterns of ionization, or low-LETs, such as γ or X… CONTINUE READING
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