High LET (56)Fe ion irradiation induces tissue-specific changes in DNA methylation in the mouse.

@article{Lima2014HighL,
  title={High LET (56)Fe ion irradiation induces tissue-specific changes in DNA methylation in the mouse.},
  author={Florence Lima and Dacheng Ding and Wilfried Goetz and Austin J. Yang and Janet E. Baulch},
  journal={Environmental and molecular mutagenesis},
  year={2014},
  volume={55 3},
  pages={266-77}
}
DNA methylation is an epigenetic mechanism that drives phenotype and that can be altered by environmental exposures including radiation. The majority of human radiation exposures occur in a relatively low dose range; however, the biological response to low dose radiation is poorly understood. Based on previous observations, we hypothesized that in vivo changes in DNA methylation would be observed in mice following exposure to doses of high linear energy transfer (LET) (56) Fe ion radiation… CONTINUE READING
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