High Incidence of Somatic BAP1 alterations in sporadic malignant mesothelioma.

  title={High Incidence of Somatic BAP1 alterations in sporadic malignant mesothelioma.},
  author={Masaki Nasu and Mitsuru Emi and Sandra Pastorino and Mika Tanji and Amy C. Powers and Hugh Luk and Francine Baumann and Yu-an Zhang and Adi Gazdar and Shreya Kanodia and Maarit Tiirikainen and Erin G. Flores and Giovanni Gaudino and Michael J. Becich and Harvey I. Pass and Haining Yang and Michele Carbone},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  volume={10 4},
BACKGROUND Breast cancer 1-associated protein 1 (BAP1) is a nuclear deubiquitinase that regulates gene expression, transcription, DNA repair, and more. Several findings underscore the apparent driver role of BAP1 in malignant mesothelioma (MM). However, the reported frequency of somatic BAP1 mutations in MM varies considerably, a discrepancy that appeared related to either methodological or ethnical differences across various studies. METHODS To address this discrepancy, we carried out… CONTINUE READING
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