High Incidence of Neuroendocrine Dysfunction in Long-Term Survivors of Aneurysmal Subarachnoid Hemorrhage

@article{Dimopoulou2004HighIO,
  title={High Incidence of Neuroendocrine Dysfunction in Long-Term Survivors of Aneurysmal Subarachnoid Hemorrhage},
  author={I. Dimopoulou and A. Kouyialis and M. Tzanella and A. Armaganidis and N. Thalassinos and D. Sakas and S. Tsagarakis},
  journal={Stroke},
  year={2004},
  volume={35},
  pages={2884-2889}
}
Background and Purpose— To investigate the incidence, pattern, and magnitude of neuroendocrine changes in long-term survivors of aneurysmal subarachnoid hemorrhage (SAH). Methods— Thirty patients (16 women) with a mean age of 50±13 years underwent endocrine assessment between 12 and 24 months after aneurysmal SAH. SAH severity was graded clinically by the Hunt & Hess scale (median, II) and radiologically by the Fisher classification (median, II). Patients underwent measurement of basal hormone… Expand
High prevalence of pituitary dysfunction after aneurysmal subarachnoid hemorrhage: a long-term prospective study using dynamic endocrine testing.
TLDR
Application of dynamic endocrine tests revealed a high frequency of long-term hypothalamic-pituitary dysfunction after aneurysmal SAH, and the role of pituitsary dysfunction in the recovery after SAH merits further evaluation. Expand
An evaluation of neuroendocrine dysfunction following acute aneurysmal subarachnoid hemorrhage: A prospective study
TLDR
Investigation of the incidence and pattern of neuroendocrine changes in cases of acute aneurysmal subarachnoid hemorrhage suggested that hormonal evaluation should be considered as part of management of acute SAH. Expand
Pituitary dysfunction after aneurysmal subarachnoid hemorrhage is associated with impaired early outcome.
TLDR
The present results support earlier findings that hormonal abnormalities are not infrequent after SAH and suggest that pituitary dysfunction is associated with worse clinical outcome and is more common among patients with bleeding sites close to the hypothalamus. Expand
Neuroendocrine dysfunction in patients recovering from subarachnoid hemorrhage
TLDR
Through a screening procedure, neuroendocrine dysfunction was identified in a substantial number of asymptomatic patients with previous SAH, and low basal levels of IGF 1 and cortisol may help in selecting patients requiring further evaluation of pituitary function. Expand
Pituitary Dysfunction After Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study.
TLDR
Pituitary dysfunction is common after aneurysmal subarachnoid hemorrhage, but does not affect 6 to 12-month clinical outcomes, and there was no correlation between pituitaries dysfunction and clinical outcome. Expand
Pituitary dysfunction after aneurysmal subarachnoid hemorrhage in Japanese patients
TLDR
It is recommended that screening pituitary dysfunction for aSAH survivors with their aneurysms located in ICA or ACA is recommended, and it was not as high as that of previous European studies. Expand
Pituitary dysfunction after aneurysmal subarachnoid haemorrhage: course and clinical predictors—the HIPS study
TLDR
Almost 40% of SAH survivors have PD, a small but substantial proportion of patients GHD or gonadotropin deficiency persists over time, and Hydrocephalus is independently associated with PD 6 months after SAH. Expand
Acute hormonal findings after aneurysmal subarachnoid hemorrhage – report from a single center
TLDR
The main finding was that hypocortisolism was rare whereas testosterone deficiency was common in male patients, and various other hormone deviations were frequent and there was wide interindividual variability during the acute phase of aSAH. Expand
Pituitary dysfunction after aneurysmal subarachnoidal hemorrhage.
TLDR
Neuroendocrine dysfunction seems to have a high prevalence in aSAH patients, even though its exact impact is not precisely known and the usage of standardized testing and reporting procedures could significantly move the field forward. Expand
Aneurysmal subarachnoid hemorrhage (aSAH) results in low prevalence of neuro-endocrine dysfunction and NOT deficiency
TLDR
Spontaneous recovery of neuro-endocrine alterations most likely presents an adaption to or dysfunction after severe illness and is strengthened by the fact that only patients with inferior clinical outcome after aSAH as assessed by GOS demonstrated neuro- endocrine dysfunction. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
Hypopituitarism following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a preliminary report.
TLDR
From this preliminary study, some degree of hypopituitarism appears to occur in approximately 40% of patients with moderate or severe head injury, with GH and gonadotroph deficiencies being most common. Expand
Pituitary deficiency following aneurysmal subarachnoid haemorrhage
TLDR
Persistent pituitary dysfunction may be more common after aneurysmal subarachnoid haemorrhage than has so far been recognised and warrants further investigation, given the possibility that some health and neurobehavioural problems in these patients could result from hormone deficiency. Expand
Psychosocial outcomes at three and nine months after good neurological recovery from aneurysmal subarachnoid haemorrhage: predictors and prognosis
TLDR
Findings highlight the need for structured support and treatment after surgery for SAH to reduce persisting mood disturbance and increase independence and participation. Expand
Recovery of hypopituitarism after neurosurgical treatment of pituitary adenomas.
TLDR
Patients with hypopituitarism after neurosurgery should be reassessed after surgery without substitution therapy, because practically half the preoperative pituitary hormone deficiencies recover postoperatively, eliminating the need for life-long substitution therapy. Expand
Hypopituitarism after surgical clipping of a ruptured cerebral aneurysm
TLDR
This case is the first one reported of hypopituitarism after surgical clipping of a ruptured cerebral aneurysm, and endocrine tests confirmed the cortisol insufficiency but also hypothyroidism and hypog onadotropic hypogonadism secondary to hypop ituitarists. Expand
Hypodipsic hypernatremia and diabetes insipidus following anterior communicating artery aneurysm clipping: diagnostic and therapeutic challenges in the amnestic rehabilitation patient
TLDR
The case of a 46-year-old male admitted for rehabilitation of functional deficits following subarachnoid haemorrhage (SAH), with clipping of an anterior communicating artery (ACoA) aneurysm, is reported, remarkable for profound short-term memory loss and inability to retain new information. Expand
HYPOTHALAMO‐PITUITARY‐ADRENAL FUNCTION FOLLOWING SUBARACHNOID HEMORRHAGE
TLDR
The results indicate that hypothalamo‐pituitaryadrenal disturbances may occur in patients surviving a subarachnoid hemorrhage and frank hypopituitarism is rare in patients who have survived more than 3.5 months. Expand
Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning.
TLDR
The results indicate that blood localized in the subarachnoid space in sufficient amount at specific sites is the only important etiological factor in vasospasm and it should be possible to identify patients in jeopardy from vasospasms and institute early preventive measures. Expand
Endocrine consequences of brain irradiation.
  • A. Toogood
  • Medicine
  • Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2004
TLDR
Patients who receive cranial irradiation that affects the hypothalamic-pituitary axis remain at risk of developing multiple hormone deficiencies for many years and require long-term follow-up by an endocrinologist. Expand
The one microgram adrenocorticotropin test in the assessment of hypothalamic-pituitary-adrenal function.
TLDR
The low-dose ACTH test is a useful, safe and inexpensive tool for the initial assessment of HPA function in patients with hypothalamic-pituitary disease and is unnecessary when cortisol peaks are greater than 750 nmol/l after 1 microg ACTH and also when very low cortisol basal levels indicate an overt hypoadrenalism. Expand
...
1
2
3
...