High IL-13 production by human neonatal T cells: neonate immune system regulator?

@article{RibeirodoCouto2001HighIP,
  title={High IL-13 production by human neonatal T cells: neonate immune system regulator?},
  author={Laura M Ribeiro-do-Couto and Leonie C. M. Boeije and Jeffrey Kroon and Berend Hooibrink and B S Breur-Vriesendorp and Lucien A. Aarden and Claire J. P. Boog},
  journal={European journal of immunology},
  year={2001},
  volume={31 11},
  pages={3394-402}
}
Neonates are highly susceptible to diseases and display biased type 2 immune responses, although no skewing to type 2 cytokines has been reported. In view of the emerging importance of IL-13 in type 2 inflammatory responses and clinical allergy, we analyzed IL-13 production by neonatal T cells. We found that, mainly CD8 T cells produced high levels of IL-13, while producing low levels of IL-4, IL-10 and IFN-gamma, upon primary and secondary stimulation. Our results point towards a possible… CONTINUE READING
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