High IL-12 p35 and IL-23 p19 mRNA expression is associated with superior outcome in ovarian cancer.

@article{Wolf2010HighIP,
  title={High IL-12 p35 and IL-23 p19 mRNA expression is associated with superior outcome in ovarian cancer.},
  author={Anna Maria Wolf and Holger Rumpold and Daniel Reimer and Christian Marth and Alain Gustave Zeimet and Dominik Georg Friedrich Wolf},
  journal={Gynecologic oncology},
  year={2010},
  volume={118 3},
  pages={244-50}
}
OBJECTIVE Interleukin-12 (IL-12) and IL-23 share a common p40 subunit that is either covalently linked to the p35 (IL-12) or to the p19 subunit (IL-23). Data from genetic animal models suggest that in contrast to the central role of IL-12 for tumor immune-surveillance, its close relative IL-23 rather promotes tumor growth. It was the aim of this project to evaluate the clinical significance of these findings. METHODS Intra-tumoral mRNA expression levels of the IL-12 specific subunit p35 and… CONTINUE READING