High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy.

@article{Litzenburger2011HighIA,
  title={High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy.},
  author={Beate Litzenburger and Chad J Creighton and Anna I. Tsimelzon and Bonita Tak-yee Chan and Susan G. Hilsenbeck and Tao Wang and Joan M. Carboni and Marco M. Gottardis and Fei Huang and Jenny C. Chang and Michael T. Lewis and Mothaffar F Rimawi and Adrian V. Lee},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 8},
  pages={2314-27}
}
PURPOSE We previously reported an insulin-like growth factor (IGF) gene expression signature, based on genes induced or repressed by IGF-I, which correlated with poor prognosis in breast cancer. We tested whether the IGF signature was affected by anti-IGF-I receptor (IGF-IR) inhibitors and whether the IGF signature correlated with response to a dual anti-IGF-IR/insulin receptor (InsR) inhibitor, BMS-754807. EXPERIMENTAL DESIGN An IGF gene expression signature was examined in human breast… CONTINUE READING

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