High-Glucose Media Enhance the Responsiveness of Tubular Cells to Growth Promoters: Effect on Lysosomal Cathepsins and Protein Degradation

@article{Schenk1998HighGlucoseME,
  title={High-Glucose Media Enhance the Responsiveness of Tubular Cells to Growth Promoters: Effect on Lysosomal Cathepsins and Protein Degradation},
  author={Ottokar Schenk and H. Ling and Katar{\'i}na {\vS}ebekov{\'a} and Spyridon Vamvakas and August Heidland},
  journal={Mineral and Electrolyte Metabolism},
  year={1998},
  volume={24},
  pages={254 - 260}
}
  • Ottokar Schenk, H. Ling, +2 authors August Heidland
  • Published in
    Mineral and Electrolyte…
    1998
  • Biology, Medicine
  • Nephromegaly is a prominent feature of diabetic nephropathy and predominantly reflects increased renal tubule mass, mostly due to hypertrophy. To elucidate pathogenetic factors involved, we studied the effects of high glucose (HG) alone, and in combination with hormones/growth promoters: angiotensin II (10–7 M); parathyroid hormone (10–7 M); insulin-like growth factor-1 (10–7 M), or transforming growth factor-β1 (TGF-β1, 10 ng/ml) in a renal cell line (LLC-PK1) with many characteristics of the… CONTINUE READING

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