High Glucose Levels Increase Major Histocompatibility Complex Class I Gene Expression in Thyroid Cells and Amplify Interferon-γ Action.

@article{Napolitano2002HighGL,
  title={High Glucose Levels Increase Major Histocompatibility Complex Class I Gene Expression in Thyroid Cells and Amplify Interferon-γ Action.},
  author={Giorgio Napolitano and Ines Bucci and Cesidio Giuliani and Cinzia Massafra and Cinzia Di Petta and Eleonora Devangelio and Dinah Singer and Fabrizio Monaco and Leonard D. Kohn},
  journal={Endocrinology},
  year={2002},
  volume={143 3},
  pages={1008-1017}
}
Increased major histocompatibility complex (MHC) class I gene expression in target tissues may be relevant to the pathogenesis of autoimmune diseases. In this study, we questioned whether high glucose levels might increase MHC class I levels and thereby contribute to autoimmune complications. We used thyrocytes in continuous culture, because there is an increased incidence of autoimmune thyroiditis in type 2 diabetics and because transcriptional regulation of MHC class I is well studied in… CONTINUE READING
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