High Glucose Attenuates Shear-Induced Changes in Endothelial Hydraulic Conductivity by Degrading the Glycocalyx

@inproceedings{LopezQuintero2013HighGA,
  title={High Glucose Attenuates Shear-Induced Changes in Endothelial Hydraulic Conductivity by Degrading the Glycocalyx},
  author={Sandra V Lopez-Quintero and Limary M. Cancel and Alexis Pierides and David A Antonetti and David C Spray and John M. Tarbell},
  booktitle={PloS one},
  year={2013}
}
Diabetes mellitus is a risk factor for cardiovascular disease; however, the mechanisms through which diabetes impairs homeostasis of the vasculature have not been completely elucidated. The endothelium interacts with circulating blood through the surface glycocalyx layer, which serves as a mechanosensor/transducer of fluid shear forces leading to biomolecular responses. Atherosclerosis localizes typically in regions of low or disturbed shear stress, but in diabetics, the distribution is more… CONTINUE READING
Highlighted Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Glycocalyx Core Proteins Selectively Mediate Endothelial NOS activation and Cell Alignment in Response to Shear Stress

  • EE Ebong, DC Spray, JM Tarbell
  • Experimental Biology – Abstract Boston, MA,
  • 2013
2 Excerpts