High Frequency of Mutations of the PIK3CA Gene in Human Cancers

@article{Samuels2004HighFO,
  title={High Frequency of Mutations of the PIK3CA Gene in Human Cancers},
  author={Y. Samuels and Z. Wang and A. Bardelli and Natalie Silliman and Janine Ptak and Steve Szabo and Hai Yan and A. Gazdar and S. Powell and G. Riggins and J. Willson and S. Markowitz and K. Kinzler and B. Vogelstein and V. Velculescu},
  journal={Science},
  year={2004},
  volume={304},
  pages={554 - 554}
}
Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important for neoplasia, including cell proliferation, adhesion, survival, and motility ([ 1 ][1]–[ 3 ][2]). To determine if PI3Ks are genetically altered in tumorigenesis, we sequenced PI3K genes in human 

Paper Mentions

Interventional Clinical Trial
It is a non-randomized, multicentric, cohort study, combined with a biological sample collection, a clinical data collection and with a genetic and immunologic biomarkers study… Expand
ConditionsNeoplasms
InterventionGenetic
Interventional Clinical Trial
Protocol YY-20394-003 is a phase I single arm, open label study. The primary objective is to assess the safety of YY-20394 in subjects with advanced solid tumor. The secondary objective… Expand
ConditionsAdvanced Solid Tumor
InterventionDrug
Interventional Clinical Trial
Protocol YY-20394-001 is a phase I open-label, first in human, dose escalation study to assess the tolerability, pharmacokinetics (PK) and efficacy of YY-20394 in patients with… Expand
ConditionsB-cell Chronic Lymphocytic Leukemia, B-cell Lymphoma Recurrent
InterventionDrug
Oncogenic Mutations of PIK3CA in Human Cancers
The PIK3CA gene is mutated with high frequency in human breast cancers
PI3K Pathway in NSCLC
Colorectal cancer: Mutations in a signalling pathway
A butterfly effect in cancer
Mutation of the PIK3CA oncogene in human cancers
Targeting RAS and PI3K in lung cancer
...
1
2
3
4
5
...

References

SHOWING 1-3 OF 3 REFERENCES
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
PIK3CA is implicated as an oncogene in ovarian cancer
Prevalence of somatic alterations in the colorectal cancer cell genome