High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.

@article{Roberts2017HighFA,
  title={High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.},
  author={Kathryn G. Roberts and Zhaohui Gu and Debbie Payne-Turner and Kelly McCastlain and Richard C Harvey and I-Ming Chen and Deqing Pei and Ilaria Iacobucci and Marcus Valentine and Stanley B Pounds and Lei Shi and Yongjin Li and Jinghui Zhang and Cheng Cheng and Alessandro Rambaldi and Manuela Tosi and Orietta Spinelli and Jerald P Radich and Mark D Minden and Jacob M. Rowe and Selina M. Luger and Mark R Litzow and Martin S. Tallman and Peter H. Wiernik and Ravi Bhatia and Ibrahim T Aldoss and Jessica Kohlschmidt and Krzysztof Mr{\'o}zek and Guido Marcucci and Clara D. Bloomfield and Wendy Stock and Stephen Kornblau and Hagop M Kantarjian and Marina Y Konopleva and Elisabeth Paietta and Cheryl L. Willman and Charles G Mullighan},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2017},
  volume={35 4},
  pages={394-401}
}
Purpose Philadelphia chromosome (Ph) -like acute lymphoblastic leukemia (ALL) is a high-risk subtype of childhood ALL characterized by kinase-activating alterations that are amenable to treatment with tyrosine kinase inhibitors. We sought to define the prevalence and genomic landscape of Ph-like ALL in adults and assess response to conventional chemotherapy. Patients and Methods The frequency of Ph-like ALL was assessed by gene expression profiling of 798 patients with B-cell ALL age 21 to 86… CONTINUE READING
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