High Frequencies of De Novo CNVs in Bipolar Disorder and Schizophrenia

@article{Malhotra2011HighFO,
  title={High Frequencies of De Novo CNVs in Bipolar Disorder and Schizophrenia},
  author={Dheeraj K Malhotra and Shane E McCarthy and Jacob J. Michaelson and Vladimir Vacic and Katherine E Burdick and Seungtai Yoon and Sven Cichon and Aiden P. Corvin and Sydney C Gary and Elliot S. Gershon and Michael Gill and Maria Karayiorgou and John R Kelsoe and Olga Krastoshevsky and Verena Krause and Ellen Leibenluft and Deborah L. Levy and Vladimir Makarov and Abhishek Bhandari and Anil K. Malhotra and Francis J. McMahon and Markus M. N{\"o}then and James B. Potash and Marcella Rietschel and Thomas G. Schulze and Jonathan Sebat},
  journal={Neuron},
  year={2011},
  volume={72},
  pages={951-963}
}
While it is known that rare copy-number variants (CNVs) contribute to risk for some neuropsychiatric disorders, the role of CNVs in bipolar disorder is unclear. Here, we reasoned that a contribution of CNVs to mood disorders might be most evident for de novo mutations. We performed a genome-wide analysis of de novo CNVs in a cohort of 788 trios. Diagnoses of offspring included bipolar disorder (n = 185), schizophrenia (n = 177), and healthy controls (n = 426). Frequencies of de novo CNVs were… CONTINUE READING
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