High Fluid Shear Stress and Spatial Shear Stress Gradients Affect Endothelial Proliferation, Survival, and Alignment

@article{Dolan2011HighFS,
  title={High Fluid Shear Stress and Spatial Shear Stress Gradients Affect Endothelial Proliferation, Survival, and Alignment},
  author={Jennifer M. Dolan and Hui Meng and Sukhjinder Singh and Rocco A Paluch and John Kolega},
  journal={Annals of Biomedical Engineering},
  year={2011},
  volume={39},
  pages={1620-1631}
}
Cerebral aneurysms develop near bifurcation apices, where complex hemodynamics occur: Flow impinges on the apex, accelerates into branches, then slows again distally, creating high wall shear stress (WSS) and positive and negative spatial gradients in WSS (WSSG). Endothelial responses to these kinds of high WSS hemodynamic environments are not well characterized. We examined endothelial cells (ECs) under elevated WSS and positive and negative WSSG using a flow chamber with constant-height… CONTINUE READING

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