High Expression of hTERT and Stemness Genes in BORIS/CTCFL Positive Cells Isolated from Embryonic Cancer Cells

@inproceedings{Alberti2014HighEO,
  title={High Expression of hTERT and Stemness Genes in BORIS/CTCFL Positive Cells Isolated from Embryonic Cancer Cells},
  author={Loredana Alberti and St{\'e}phanie Renaud and Lorena Losi and Serge Leyvraz and Jean Benhattar and Gabriele Saretzki},
  booktitle={PloS one},
  year={2014}
}
  • Loredana Alberti, Stéphanie Renaud, +3 authors Gabriele Saretzki
  • Published in PloS one 2014
  • Medicine, Biology
  • BORIS/CTCFL is a member of cancer testis antigen family normally expressed in germ cells. In tumors, it is aberrantly expressed although its functions are not completely well-defined. To better understand the functions of BORIS in cancer, we selected the embryonic cancer cells as a model. Using a molecular beacon, which specifically targets BORIS mRNA, we demonstrated that BORIS positive cells are a small subpopulation of tumor cells (3-5% of total). The BORIS-positive cells isolated using… CONTINUE READING

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