High EZH2 expression is correlated to metastatic disease in pediatric soft tissue sarcomas

Abstract

Enhancer of Zeste Drosophila Homologue 2 (EZH2) is a key regulator of transcription as a member of polycomb repressive complex 2 (PRC2) which exerts repression of downstream genes and is correlated to invasiveness and progression of different tumours. Therefore, we evaluated the expression of PRC2 proteins in pediatric soft tissue sarcoma (rhabdomyosarcoma… (More)
DOI: 10.1186/s12935-016-0338-x

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