High-Dose siRNAs Upregulate Mouse Eri-1 at both Transcription and Posttranscription Levels

@inproceedings{Bian2011HighDoseSU,
  title={High-Dose siRNAs Upregulate Mouse Eri-1 at both Transcription and Posttranscription Levels},
  author={Yingnan Bian and Wei Zhou and Yingchun Zhao and Xiaoping Li and Wei Geng and Ruixin Hao and Qing Yang and Weida Huang},
  booktitle={PloS one},
  year={2011}
}
The eri-1 gene encodes a 3' exonuclease that can negatively regulate RNA interference via siRNase activity. High-dose siRNAs (hd-siRNAs) can enhance Eri-1 expression, which in return degrade siRNAs and greatly reduces RNAi efficiency. Here we report that hd-siRNAs induce mouse Eri-1 (meri-1) expression through the recruitment of Sp1, Ets-1, and STAT3 to the meri-1 promoter and the formation of an Sp1-Ets-1-STAT3 complex. In addition, hd-siRNAs also abolish the 3' untranslated region (UTR… CONTINUE READING
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