High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial.

@article{Billings2016HighDosePA,
  title={High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial.},
  author={Frederic T. Billings and Patricia A Hendricks and Jonathan S. Schildcrout and Yaping Shi and Michael R. Petracek and John G. Byrne and Nancy J. Brown},
  journal={JAMA},
  year={2016},
  volume={315 9},
  pages={877-88}
}
IMPORTANCE Statins affect several mechanisms underlying acute kidney injury (AKI). OBJECTIVE To test the hypothesis that short-term high-dose perioperative atorvastatin would reduce AKI following cardiac surgery. DESIGN, SETTING, AND PARTICIPANTS Double-blinded, placebo-controlled, randomized clinical trial of adult cardiac surgery patients conducted from November 2009 to October 2014 at Vanderbilt University Medical Center. INTERVENTIONS Patients naive to statin treatment (n = 199) were… CONTINUE READING
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