High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease.

@article{Mrdjen2018HighDimensionalSM,
  title={High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease.},
  author={Dunja Mrdjen and Anto Pavlovic and Felix J Hartmann and Bettina Schreiner and Sebastian G Utz and Brian P. Leung and Iva Lelios and Frank L Heppner and Jonathan Kipnis and Doron Merkler and Melanie Greter and Burkhard Becher},
  journal={Immunity},
  year={2018},
  volume={48 2},
  pages={
          380-395.e6
        }
}
Individual reports suggest that the central nervous system (CNS) contains multiple immune cell types with diverse roles in tissue homeostasis, immune defense, and neurological diseases. It has been challenging to map leukocytes across the entire brain, and in particular in pathology, where phenotypic changes and influx of blood-derived cells prevent a clear distinction between reactive leukocyte populations. Here, we applied high-dimensional single-cell mass and fluorescence cytometry, in… CONTINUE READING
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