High-Dimensional Bayesian Optimization of Personalized Cardiac Model Parameters via an Embedded Generative Model

  title={High-Dimensional Bayesian Optimization of Personalized Cardiac Model Parameters via an Embedded Generative Model},
  author={J. Dhamala and Sandesh Ghimire and John L. Sapp and B. Milan Hor{\'a}{\vc}ek and Linwei Wang},
The estimation of patient-specific tissue properties in the form of model parameters is important for personalized physiological models. However, these tissue properties are spatially varying across the underlying anatomical model, presenting a significance challenge of high-dimensional (HD) optimization at the presence of limited measurement data. A common solution to reduce the dimension of the parameter space is to explicitly partition the anatomical mesh, either into a fixed small number of… 

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