High Density Lipoprotein Nanoparticles Deliver RNAi to Endothelial Cells to Inhibit Angiogenesis.

@article{Tripathy2014HighDL,
  title={High Density Lipoprotein Nanoparticles Deliver RNAi to Endothelial Cells to Inhibit Angiogenesis.},
  author={Sushant Tripathy and Elena Vinokour and Kaylin Marie McMahon and Olga V. Volpert and C Shad Thaxton},
  journal={Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems},
  year={2014},
  volume={31 11},
  pages={1141-1150}
}
Systemic delivery of therapeutic nucleic acids to target cells and tissues outside of the liver remains a major challenge. We synthesized a biomimetic high density lipoprotein nanoparticle (HDL NP) for delivery of a cholesteryl modified therapeutic nucleic acid (RNAi) to vascular endothelial cells, a cell type naturally targeted by HDL. HDL NPs adsorb cholesteryl modified oligonucleotides and protect them from nuclease degradation. As proof of principle, we delivered RNAi targeting vascular… CONTINUE READING