High D-glucose stimulates the cell cycle from the G1 to the S and M phases, but has no competent effect on the G0 phase, in vascular smooth muscle cells.

@article{Hiroishi1995HighDS,
  title={High D-glucose stimulates the cell cycle from the G1 to the S and M phases, but has no competent effect on the G0 phase, in vascular smooth muscle cells.},
  author={Goro Hiroishi and Sei Kobayashi and Junji Nishimura and Hajime Inomata and Hideo Kanaide},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={211 2},
  pages={619-26}
}
The effects of high (28mM) D-glucose (HG) on the cell cycle progression were investigated in rat aorta vascular smooth muscle cells (VSMCs) in primary culture, using an immunocytochemical analysis of cell-cycle-specific nuclear antigens. HG had no effect on the cell cycle of the serum-deprived G0 cells, whereas platelet-derived growth factor (PDGF) stimulated the entry of the G0 cells to the G1 phase without a further progression to the S and M phases. HG, but neither mannitol nor L-glucose… CONTINUE READING

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