High Content Screening Using New U2OS Reporter Cell Models Identifies Harmol Hydrochloride as a Selective and Competitive Antagonist of the Androgen Receptor

@article{Dellal2020HighCS,
  title={High Content Screening Using New U2OS Reporter Cell Models Identifies Harmol Hydrochloride as a Selective and Competitive Antagonist of the Androgen Receptor},
  author={Hadjer Dellal and A. Boulahtouf and Elina Alaterre and Alice Cuenant and M. Grimaldi and W. Bourguet and C. Gongora and P. Balaguer and P. Pourquier},
  journal={Cells},
  year={2020},
  volume={9}
}
Prostate cancer is the most commonly diagnosed malignancy in men. Its growth mainly relies on the activity of the androgen receptor (AR), justifying the use of androgen deprivation therapy as a gold standard treatment for the metastatic disease. Inhibition of the androgen axis using second generation antagonists has improved patients’ survival, but is systematically confronted to resistance mechanisms, leading to a median survival that does not exceed 5 years. Counteracting this resistance has… Expand

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