High Concentration of Vitamin E Decreases Thermosensation and Thermotaxis Learning and the Underlying Mechanisms in the Nematode Caenorhabditis elegans

@article{Li2013HighCO,
  title={High Concentration of Vitamin E Decreases Thermosensation and Thermotaxis Learning and the Underlying Mechanisms in the Nematode Caenorhabditis elegans},
  author={Yiping Li and Yinxia Li and Qiuli Wu and Huayue Ye and Lingmei Sun and Boping Ye and Dayong Wang},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
α-tocopherol is a powerful liposoluble antioxidant and the most abundant isoform of vitamin E in the body. Under normal physiological conditions, adverse effects of relatively high concentration of vitamin E on organisms and the underlying mechanisms are still largely unclear. In the present study, we used the nematode Caenorhabditis elegans as an in vivo assay system to investigate the possible adverse effects of high concentration of vitamin E on thermosensation and thermotaxis learning and… Expand
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References

SHOWING 1-10 OF 127 REFERENCES
Induction of chemotaxis to sodium chloride and diacetyl and thermotaxis defects by microcystin-LR exposure in nematode Caenorhabditis elegans.
TLDR
Evidence is provided to indicate the neurotoxicity on chemotaxis to NaCl and diacetyl, and thermotaxis from MC-LR exposure to C. elegans is largely mediated by the damage on the corresponding sensory neurons (ASE, AWA, and AFD) and interneuron AIY. Expand
Transgenerational, ultrastructural analysis on the antioxidative effects of tocopherol on early gametogenesis in Caenorhabditis elegans grown in 100% oxygen.
TLDR
The presence of enhanced levels of intracellular Vitamin E resulted in protection against oxidative stress during gametogenesis, and Vitamin E was also shown to have a protective effect against paraquat, which is a strong, intrACEllular, oxidizing agent. Expand
Neural regulation of thermotaxis in Caenorhabditis elegans
TLDR
A neural model is proposed in which regulation of the activities of the two interneurons in opposite directions, depending on the cultivation temperature, is essential for thermotaxis, and an amphid sensory neuron, AFD, is a major thermosensory neuron. Expand
Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans.
  • H. Adachi, N. Ishii
  • Medicine
  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2000
TLDR
The administration of tocotrienols to animals results in a reduction of oxidative stress risks, and it is suggested that C. elegans will continue to provide provocative clues into the mechanisms of aging. Expand
Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegans
TLDR
The data suggest that vitamin E increases lifespan in C. elegans in part by slowing development in the same manner that metabolic-depressant or mildly cytotoxic drugs increase lifespan, decrease fecundity, and delay the timing of reproduction. Expand
Evaluation of the long-term memory for thermosensation regulated by neuronal calcium sensor-1 in Caenorhabditis elegans
TLDR
The thermotaxis tracking model is suitable for evaluating the LTM regulated by NCS-1, and can be employed for elucidating regulatory functions of specific genes or effects of stimuli on memory in C. elegans. Expand
Evaluation of the long-term memory for thermosensation regulated by neuronal calcium sensor-1 in Caenorhabditis elegans
To evaluate whether the thermotaxis tracking model is suitable for assessing long-term memory (LTM) in the nematode Caenorhabditis elegans. Animals were trained at 20 °C overnight in presence ofExpand
Trace administration of vitamin E can retrieve and prevent UV-irradiation- and metal exposure-induced memory deficits in nematode Caenorhabditis elegans
TLDR
Treatment with 200microg/mL of vitamin E could restore the memory deficits formed in the ncs-1 mutant worms, suggesting that exogenous treatment with trace vitamin E can largely mimic the function of NCS-1 in regulating the memory for thermosensation. Expand
Alpha-tocopherol ameliorates cypermethrin-induced toxicity and oxidative stress in the nematode Caenorhabdtis elegans.
TLDR
It is suggested that CYP induces oxidative stress in Caenorhabditis elegans and the strategy of intervention with alpha-tocopherol could be exploited to offset this induced oxidative stress. Expand
Effects of Metal Exposure on Associative Learning Behavior in Nematode Caenorhabditis elegans
TLDR
Pb and Hg were the more toxic among the examined metals, with severe toxicity on associative learning behavior, thermotaxis, and locomotion behavior in nematodes. Expand
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5
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