High Ca2+ permeability of a peptide-gated DEG/ENaC from Hydra

@inproceedings{Drrnagel2012HighCP,
  title={High Ca2+ permeability of a peptide-gated DEG/ENaC from Hydra},
  author={Stefan Johannes D{\"u}rrnagel and Bj{\"o}rn H Falkenburger and Stefan Gr{\"u}nder},
  booktitle={The Journal of general physiology},
  year={2012}
}
Degenerin/epithelial Na(+) channels (DEG/ENaCs) are Na(+) channels that are blocked by the diuretic amiloride. In general, they are impermeable for Ca(2+) or have a very low permeability for Ca(2+). We describe here, however, that a DEG/ENaC from the cnidarian Hydra magnipapillata, the Hydra Na(+) channel (HyNaC), is highly permeable for Ca(2+) (P(Ca)/P(Na) = 3.8). HyNaC is directly gated by Hydra neuropeptides, and in Xenopus laevis oocytes expressing HyNaCs, RFamides elicit currents with… CONTINUE READING
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