High CO2 chemosensitivity versus wide sensing spectrum: a paradoxical problem and its solutions in cultured brainstem neurons.

@article{Su2007HighCC,
  title={High CO2 chemosensitivity versus wide sensing spectrum: a paradoxical problem and its solutions in cultured brainstem neurons.},
  author={Junda Su and Liang Yang and Xiaoli Zhang and Asheebo Rojas and Yun Zhong Shi and Chun Jiang},
  journal={The Journal of physiology},
  year={2007},
  volume={578 Pt 3},
  pages={831-41}
}
CO2 central chemoreceptors play an important role in cardiorespiratory control. They are highly sensitive to P(CO2) in a broad range. These two sensing properties seem paradoxical as none of the known pH-sensing molecules can achieve both. Here we show that cultured neuronal networks are likely to solve the sensitivity versus spectrum problem with parallel and serial processes. Studies were performed on dissociated brainstem neurons cultured on microelectrode arrays. Recordings started after a… CONTINUE READING