High CCR4 expression in the tumor microenvironment is a poor prognostic indicator in lung adenocarcinoma.

@article{Karasaki2018HighCE,
  title={High CCR4 expression in the tumor microenvironment is a poor prognostic indicator in lung adenocarcinoma.},
  author={Takahiro Karasaki and Guangliang Qiang and Masaki Anraku and Yanbin Sun and Aya Shinozaki-Ushiku and Eiichi Sato and Kosuke Kashiwabara and Kazuhiro Nagayama and Jun-ichi Nitadori and Masaaki Sato and Tomohiro Murakawa and Kazuhiro Kakimi and Masashi Fukayama and Jun Nakajima},
  journal={Journal of thoracic disease},
  year={2018},
  volume={10 8},
  pages={
          4741-4750
        }
}
Background Clinical trials of anti-CCR4 antibody for solid cancers with or without other immune-modulating agents including immune checkpoint blockade therapy are currently underway. However, little is known about the roles of CCR4+ lymphocytes and their prognostic impact in lung cancer. We hypothesized that high CCR4 expression in the tumor microenvironment would be associated with a poor prognosis and would act as a biomarker in lung adenocarcinoma. Methods First, the prognostic impact of… CONTINUE READING
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