High Basal Activity of the PTPN22 Gain-of-Function Variant Blunts Leukocyte Responsiveness Negatively Affecting IL-10 Production in ANCA Vasculitis

@inproceedings{Cao2012HighBA,
  title={High Basal Activity of the PTPN22 Gain-of-Function Variant Blunts Leukocyte Responsiveness Negatively Affecting IL-10 Production in ANCA Vasculitis},
  author={Yali Cao and Jiajin Yang and Kerry R Colby and Susan Leininger Hogan and Yichun Hu and Caroline E. Jennette and Elisabeth Berg and Youkang Zhang and J. Charles Jennette and Ronald J. Falk and Gloria A. Preston},
  booktitle={PloS one},
  year={2012}
}
Consequences of expression of the protein tyrosine phosphatase nonreceptor 22 (PTPN22) gain-of-function variant were evaluated in leukocytes from patients with anti-neutrophil cytoplasmic autoantibody (ANCA) disease. The frequency of the gain-of-function allele within the Caucasian patient cohort was 22% (OR 1.45), compared to general American Caucasian population (16.5%, p = 0.03). Examination of the basal phosphatase activity of PTPN22 gain-of-function protein indicated persistently elevated… CONTINUE READING