High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

@article{Chavan2015HighAffinityIO,
  title={High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.},
  author={Tanmay S. Chavan and Hyunbum Jang and Lyuba Khavrutskii and Sherwin J. Abraham and Avik Banerjee and Benjamin C. Freed and Liv Johannessen and Sergey G Tarasov and Vadim Gaponenko and Ruth Nussinov and Nadya I. Tarasova},
  journal={Biophysical journal},
  year={2015},
  volume={109 12},
  pages={
          2602-2613
        }
}
Ras proteins are small GTPases that act as signal transducers between cell surface receptors and several intracellular signaling cascades. They contain highly homologous catalytic domains and flexible C-terminal hypervariable regions (HVRs) that differ across Ras isoforms. KRAS is among the most frequently mutated oncogenes in human tumors. Surprisingly, we found that the C-terminal HVR of K-Ras4B, thought to minimally impact the catalytic domain, directly interacts with the active site of the… CONTINUE READING
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