High Affinity Binding of 125I-Neurotensin to Dispersed Cells from Chicken Liver and Brain

@article{Mitra1997HighAB,
  title={High Affinity Binding of 125I-Neurotensin to Dispersed Cells from Chicken Liver and Brain},
  author={S. P. Mitra and R. Carraway},
  journal={Peptides},
  year={1997},
  volume={18},
  pages={521-525}
}
  • S. P. Mitra, R. Carraway
  • Published 1997
  • Biology, Medicine
  • Peptides
  • Dispersed cells from chicken brain and liver were found to possess cell surface binding sites for 125I-neurotensin (125I-NT). Scatchard analyses indicated the presence of high affinity (K4, 25-80 pM) and low affinity (Kd, 250-450 pM) components in adult tissues. Binding capacity was reduced 25-40% by incubation with pertussis toxin. Ontogenetic studies indicated that NT receptor capacity increased approximately 20-fold from the embryonic stage to adult. Cross-linking of 125I-NT to intact cells… CONTINUE READING
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