High Accuracy Mutation Detection in Leukemia on a Selected Panel of Cancer Genes

  title={High Accuracy Mutation Detection in Leukemia on a Selected Panel of Cancer Genes},
  author={Zeynep Kalender Atak and Kim De Keersmaecker and Valentina Gianfelici and Ellen Geerdens and Roel Vandepoel and Daphnie Pauwels and Micha{\"e}l Porcu and Idoya Lahortiga and Vanessa Brys and Wilhelm G Dirks and Hilmar Quentmeier and Jacqueline Cloos and Harry Cuppens and Anne Uyttebroeck and Peter Vandenberghe and Jan Cools and Stein Aerts},
  booktitle={PloS one},
With the advent of whole-genome and whole-exome sequencing, high-quality catalogs of recurrently mutated cancer genes are becoming available for many cancer types. Increasing access to sequencing technology, including bench-top sequencers, provide the opportunity to re-sequence a limited set of cancer genes across a patient cohort with limited processing time. Here, we re-sequenced a set of cancer genes in T-cell acute lymphoblastic leukemia (T-ALL) using Nimblegen sequence capture coupled with… CONTINUE READING
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