High Abundance of GluR1 mRNA and Reduced Q/R Editing of GluR2 mRNA in Individual NADPH-Diaphorase Neurons

  title={High Abundance of GluR1 mRNA and Reduced Q/R Editing of GluR2 mRNA in Individual NADPH-Diaphorase Neurons},
  author={Doo Yeon Kim and Sun Hee Kim and Hyun B. Choi and Chul-ki Min and Byoung Joo Gwag},
  journal={Molecular and Cellular Neuroscience},
Striatal and cortical neurons containing NADPH-diaphorase [NADPH-d(+)] are highly vulnerable to excitotoxicity that is induced by activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)- or kainate-sensitive glutamate receptors. This has been attributed to Ca2+ entry through AMPA/kainate receptors in NADPH-d(+) neurons. In this study, we applied single cell RT-PCR technique to test the hypothesis that differences in levels and processing of the GluR2 subunit would… 

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