High &bgr;1‐Selectivity and Favourable Pharmacokinetics as the Outstanding Properties of Bisoprolol

  title={High \&bgr;1‐Selectivity and Favourable Pharmacokinetics as the Outstanding Properties of Bisoprolol},
  author={Guenther Haeusler and H. J. Schliep and Pierre Schelling and K. H. Becker and Michael Dr Klockow and Klaus Minck and H. J. Enenkel and E. Schulze and R. Bergmann and Claus J. Dr. Schmitges and Christoph A. Seyfried and J{\"u}rgen Harting},
  journal={Journal of Cardiovascular Pharmacology},
&NA; Bisoprolol, (±)1‐(4‐[(2‐isopropoxyethoxy)‐methyl]‐phenoxy)‐3‐isopropyl‐amino‐2‐propanol‐hemifumarate, is a new, highly selective &bgr;1‐adrenoceptor blocking agent without intrinsic sympathomimetic activity and low to moderate local anaesthetic activity. As demonstrated in binding experiments, and in classical pharmacological studies using rats, guinea pigs, cats, and dogs, bisoprolol markedly differentiated between &bgr;1‐adrenoceptors of the heart, or the renal juxtaglomerular apparatus… Expand
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