High‐resolution oligonucleotide array‐CGH applied to the detection and characterization of large rearrangements in the hereditary breast cancer gene BRCA1

@article{Rouleau2007HighresolutionOA,
  title={High‐resolution oligonucleotide array‐CGH applied to the detection and characterization of large rearrangements in the hereditary breast cancer gene BRCA1},
  author={Etienne Rouleau and C{\'e}drick Lefol and Sengül Tozlu and Catherine Andrieu and Christophe Guy and F Copigny and Catherine Noguès and Ivan Bi{\`e}che and Rosette Lidereau},
  journal={Clinical Genetics},
  year={2007},
  volume={72}
}
We have developed a new method for detecting and characterizing large rearrangements in the BRCA1 gene based on high‐resolution oligonucleotide array‐CGH technology. We designed a specific CGH array for the BRCA1 gene and its flanking regions. We then used this approach to analyze nine DNA samples known to contain large deletions and large duplications. When possible, the deleted or duplicated region was sequenced to identify the break point. All the large rearrangements were detected by the… 
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