• DOI:10.1111/j.1348-0421.2002.tb02711.x
Corpus ID: 22593331

High‐Level Fluoroquinolone Resistance in Pseudomonas aeruginosa Due to Interplay of the MexAB‐OprM Efflux Pump and the DNA Gyrase Mutation

@article{Nakajima2002HighLevelFR,
  title={High‐Level Fluoroquinolone Resistance in Pseudomonas aeruginosa Due to Interplay of the MexAB‐OprM Efflux Pump and the DNA Gyrase Mutation},
  author={A. Nakajima and Y. Sugimoto and H. Yoneyama and T. Nakae},
  journal={Microbiology and Immunology},
  year={2002},
  volume={46}
}

A. Nakajima, Y. Sugimoto, +1 author T. Nakae

Published 2002

Biology, Medicine

Microbiology and Immunology

Fluoroquinolone resistance in Pseudomonas aeruginosa is mainly attributable to the constitutive expression of the xenobiotic efflux pump and mutation in DNA gyrase or topoisomerase IV. We constructed cells with a double‐mutation in gyrA and mexR encoding DNA gyrase and repressor for the mexAB‐oprM operon, respectively. The mutant showed 1,024 times higher fluoroquinolone resistance than cells lacking the MexAB‐OprM. Cells with a single mutation in gyrA and producing a wild‐type level of the… CONTINUE READING

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