High‐Level Fluoroquinolone Resistance in Pseudomonas aeruginosa Due to Interplay of the MexAB‐OprM Efflux Pump and the DNA Gyrase Mutation

@article{Nakajima2002HighLevelFR,
  title={High‐Level Fluoroquinolone Resistance in Pseudomonas aeruginosa Due to Interplay of the MexAB‐OprM Efflux Pump and the DNA Gyrase Mutation},
  author={A. Nakajima and Y. Sugimoto and H. Yoneyama and T. Nakae},
  journal={Microbiology and Immunology},
  year={2002},
  volume={46}
}
  • A. Nakajima, Y. Sugimoto, +1 author T. Nakae
  • Published 2002
  • Biology, Medicine
  • Microbiology and Immunology
  • Fluoroquinolone resistance in Pseudomonas aeruginosa is mainly attributable to the constitutive expression of the xenobiotic efflux pump and mutation in DNA gyrase or topoisomerase IV. We constructed cells with a double‐mutation in gyrA and mexR encoding DNA gyrase and repressor for the mexAB‐oprM operon, respectively. The mutant showed 1,024 times higher fluoroquinolone resistance than cells lacking the MexAB‐OprM. Cells with a single mutation in gyrA and producing a wild‐type level of the… CONTINUE READING
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    References

    SHOWING 1-10 OF 13 REFERENCES
    The role of mex-gene products in antibiotic extrusion in Pseudomonas aeruginosa.
    • 33