Hierarchy of models: from qualitative to quantitative analysis of circadian rhythms in cyanobacteria.

@article{Chaves2013HierarchyOM,
  title={Hierarchy of models: from qualitative to quantitative analysis of circadian rhythms in cyanobacteria.},
  author={Madalena Chaves and Miguel Torres Preto},
  journal={Chaos},
  year={2013},
  volume={23 2},
  pages={
          025113
        }
}
A hierarchy of models, ranging from high to lower levels of abstraction, is proposed to construct "minimal" but predictive and explanatory models of biological systems. Three hierarchical levels will be considered: Boolean networks, piecewise affine differential (PWA) equations, and a class of continuous, ordinary, differential equations' models derived from the PWA model. This hierarchy provides different levels of approximation of the biological system and, crucially, allows the use of… CONTINUE READING

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