Hierarchy of ADAM12 binding to integrins in tumor cells.

  title={Hierarchy of ADAM12 binding to integrins in tumor cells.},
  author={Charles Kumar Thodeti and Camilla Fr{\"o}hlich and Christian Kamp Nielsen and Peter Holck and Christina Sundberg and Marie Kveiborg and Yashithra Mahalingam and Reidar Albrechtsen and John Robert Couchman and Ulla M. Wewer},
  journal={Experimental cell research},
  volume={309 2},
ADAMs (a disintegrin and metalloprotease) comprise a family of cell surface proteins with protease and cell-binding activities. Using different forms and fragments of ADAM12 as substrates in cell adhesion and spreading assays, we demonstrated that alpha9beta1 integrin is the main receptor for ADAM12. However, when alpha9beta1 integrin is not expressed--as in many carcinoma cells--other members of the beta1 integrin family can replace its ligand binding activity. In attachment assays, the… CONTINUE READING


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