Hierarchy in gene expression is predictive of risk, progression, and outcome in adult acute myeloid leukemia.

@article{Tripathi2015HierarchyIG,
  title={Hierarchy in gene expression is predictive of risk, progression, and outcome in adult acute myeloid leukemia.},
  author={Shubham Tripathi and Michael W. Deem},
  journal={Physical biology},
  year={2015},
  volume={12 1},
  pages={016016}
}
Cancer progresses with a change in the structure of the gene network in normal cells. We define a measure of organizational hierarchy in gene networks of affected cells in adult acute myeloid leukemia (AML) patients. With a retrospective cohort analysis based on the gene expression profiles of 116 AML patients, we find that the likelihood of future cancer relapse and the level of clinical risk are directly correlated with the level of organization in the cancer related gene network. We also… CONTINUE READING
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