Hierarchization of animal teratology findings for improving the human risk evaluation of drugs.

Abstract

The risk assessment of drugs in pregnancy can be improved through better knowledge and interpretation of significant experimental findings. Embryo-fetal effects can be considered as the endpoint of importance, after excluding that their occurrence is related to maternal toxicity. If embryo-fetal toxic effects occur in the presence of maternal toxicity, the… (More)

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@article{Guittina2000HierarchizationOA, title={Hierarchization of animal teratology findings for improving the human risk evaluation of drugs.}, author={P Guittina and Erica Elefant and B Saint-Salvi}, journal={Reproductive toxicology}, year={2000}, volume={14 4}, pages={369-75} }