Hierarchical self-assembly of amelogenin and the regulation of biomineralization at the nanoscale.

@article{Fang2011HierarchicalSO,
  title={Hierarchical self-assembly of amelogenin and the regulation of biomineralization at the nanoscale.},
  author={Ping-An Fang and James F Conway and Henry C. Margolis and James P. Simmer and Elia Beniash},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 34},
  pages={14097-102}
}
Enamel is a highly organized hierarchical nanocomposite, which consists of parallel arrays of elongated apatitic crystallites forming an intricate three-dimensional microstructure. Amelogenin, the major extracellular matrix protein of dental enamel, regulates the formation of these crystalline arrays via cooperative interactions with forming mineral phase. Using cryoelectron microscopy, we demonstrate that amelogenin undergoes stepwise hierarchical self-assembly. Furthermore, our results… CONTINUE READING
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