Hierarchical rules for Argonaute loading in Drosophila.

  title={Hierarchical rules for Argonaute loading in Drosophila.},
  author={Benjamin Czech and Rui Zhou and Yaniv Erlich and J. Brennecke and Richard Binari and Christians Villalta and Assaf Gordon and Norbert Perrimon and Gregory J Hannon},
  journal={Molecular cell},
  volume={36 3},
Drosophila Argonaute-1 and Argonaute-2 differ in function and small RNA content. AGO2 binds to siRNAs, whereas AGO1 is almost exclusively occupied by microRNAs. MicroRNA duplexes are intrinsically asymmetric, with one strand, the miR strand, preferentially entering AGO1 to recognize and regulate the expression of target mRNAs. The other strand, miR*, has been viewed as a byproduct of microRNA biogenesis. Here, we show that miR*s are often loaded as functional species into AGO2. This indicates… CONTINUE READING
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