Hierarchical radial and polar organisation of chromosomes in human sperm

@article{Millan2012HierarchicalRA,
  title={Hierarchical radial and polar organisation of chromosomes in human sperm},
  author={Nicole M. Millan and Paulina Lau and Michael Christopher Hann and Dimitris Ioannou and David D. Hoffman and Meritxell Barrionuevo and Wayne S. Maxson and Sophie Ory and H. G. Tempest},
  journal={Chromosome Research},
  year={2012},
  volume={20},
  pages={875-887}
}
It is well established that chromosomes occupy distinct positions within the interphase nuclei, conferring a potential functional implication to the genome. In addition, alterations in the nuclear organisation patterns have been associated with disease phenotypes (e.g. cancer or laminopathies). The human sperm is the smallest cell in the body with specific DNA packaging and the mission of delivering the paternal genome to the oocyte during fertilisation. Studies of nuclear organisation in the… CONTINUE READING
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