Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes

@inproceedings{Frank2017HierarchicalOA,
  title={Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes},
  author={Ren{\'e} A. W. Frank and Fei Zhu and N. Hennakao Komiyama and Seth G. N. Grant},
  booktitle={Journal of neurochemistry},
  year={2017}
}
PSD95 is an abundant postsynaptic scaffold protein in glutamatergic synapses that assembles into supercomplexes composed of over 80 proteins including neurotransmitter receptors, ion channels and adhesion proteins. How these diverse constituents are organized into PSD95 supercomplexes in vivo is poorly understood. Here, we dissected the supercomplexes in mice combining endogenous gene-tagging, targeted mutations and quantitative biochemical assays. Generating compound heterozygous mice with two… CONTINUE READING
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