Hierarchical interactions of homeodomain and forkhead transcription factors in regulating odontogenic gene expression.

Abstract

FoxJ1 is a forkhead transcription factor expressed in multiple tissues during development and a major regulator of cilia development. FoxJ1(-/-) mice present with defects in odontogenesis, and we correlate these defects to hierarchical interactions between homeodomain factors Pitx2 and Dlx2 with FoxJ1 in regulating their expression through direct physical… (More)
DOI: 10.1074/jbc.M111.252031

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